Olumiant (baricitinib) is a prescription medicine called a Janus kinase (JAK) inhibitor used to treat adults with moderately to severely active rheumatoid arthritis after treatment with 1 or more medicines called tumor necrosis factor (TNF) blockers have been used, and did not work well enough or could not be tolerated.
Your signs and symptoms may improve in as few as 7 days
In a study, some people taking Olumiant experienced a 20% improvement in the signs and symptoms of their RA in as few as 7 days. Others saw results in 12 weeks.
Olumiant may help people with RA experience fewer signs and symptoms such as:
- Joint pain
Select Safety Information
Olumiant may cause serious side effects, including:
Changes in laboratory test results. Your doctor should do blood tests to check your white and red blood cells before and while you are taking Olumiant. Your doctor should also check certain liver tests. You should not take Olumiant if your blood cell counts are too low or your liver tests are too high. If your results change, your doctor may pause your treatment with Olumiant. Your doctor should also check your cholesterol approximately 12 weeks after you start this medicine and as needed after that.
How does Olumiant work?
Olumiant is a Janus kinase (JAK) inhibitor. JAK inhibitors help disrupt how cells respond to some cytokines. Cytokines are proteins that allow cells to communicate with each other, and excess cytokines may cause inflammation. In RA, joint inflammation may cause pain, swelling, and tenderness. It is not known which disrupted cytokines are most related to the therapeutic effects of Olumiant.
Talking to your doctor
It's important to track your rheumatoid arthritis (RA) symptoms and talk to your doctor about how you're feeling. Even mentioning small things that have changed can help with managing your RA. The more your doctor knows about your overall health and how your symptoms are affecting your ability to do things at work and at home, the better prepared he or she will be to evaluate which treatment is most appropriate for you.
To get started, you may want to ask yourself these following questions:
- Am I noticing changes in my RA symptoms, such as joint pain, stiffness, or swelling?
- If joint swelling was present, has it decreased or does it still persist?
- Have I seen changes in my physical function in performing day-to-day tasks?
- How many times a week am I feeling like I’ve had a “good” day with RA?
- What does a "good" day with RA mean for me?
- Am I able to do the tasks I enjoy doing?
- What is something I have trouble doing because of my RA? How do I go about doing that thing differently because of my RA?
- What are some of the activities I'd do more often if my RA was better controlled?
- Have I taken too many sick days?
Additional helpful resources and tools are available from the Arthritis Foundation at arthritis.org .